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Around him, Padlock recruited a fantastic team of other skilled R&D execs, like Head of Biology Mariana Nacht (who was previously with Atlas-backed Avila, and prior to that Genzyme) and our St.
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Co-founder and CEO Mike Gilman is a well-known serial entrepreneur, having led Stromedix previously (a prior Atlas investment), as well as tours of duty at Biogen and Ariad. Serial industry veterans, all trained in large biopharma, nucleated this small but high-performing team.So the science here is both big and bold, and offers a different angle on treating disease. Beyond RA, there are clear applications in Lupus, MS, and many other autoimmune diseases. To make the story even more exciting, researchers have discovered that a subset of RA patients with highly erosive disease have PAD-activating auto-antibodies, which leads to massive extracellular citrullination and presumably neoantigen formation, providing the company with a targeted, easy-to-identify patient population.
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In other words, instead of blocking the flames, Padlock aims to stop fueling the sparks that cause them. Our PAD-focused approach, while tautologically aligned with how we all understand autoimmunity in textbooks, is actually orthogonal to how most current drugs treat the disease: the vast pharmacopeia in autoimmune disease is largely about blocking the inflammatory mediators circulating in the body, rather than blocking the cause of their production in the first place. A much more elegant description of the science around PADs is covered in a blog by Gilman titled “ Rekindling the Flame”. Padlock’s scientific approach could be summarized in two short sentences: autoimmune disease is caused by autoantigens, and blocking the creation of those autoantigens will ameliorate the pathology.
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We were well on our way to building a great ‘big biology’ company when partnership interest heated up for the company, culminating with BMS’ acquisition today.Īs I’ve done in the past, I thought I’d share a few of the inside-baseball perspectives on the company and what made the story special: “Padlock West” ( here).įast forward to today, we’re poised to enter formal preclinical development on our lead program and anticipate generating clinical data on the approach in the next couple years, with a portfolio of other PAD programs advancing behind it. And a couple months ago, we moved from a purely virtual model into a “hybrid” one, setting up some targeted labs in Cambridge and out in San Diego, a.k.a.
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Early in 2015, as our lead optimization campaign began moving into full force, we licensed some PAD-related patents and know-how from GSK to help accelerate our efforts, in exchange for some early equity in the startup ( here).
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We syndicated the initial tranche of the Series A with with JJDC and MerckSerono Ventures, and later added Index Ventures ( here). The seed phase objective was a focused de-risking plan around identifying initial chemical matter of sufficient quality. The new startup, pre-funding, joined the backend of our Seed Class of 2013, although the initial investment didn’t happen until the winter of 2014. Working with serial entrepreneur Mike Gilman, who had just returned to Atlas from a stint at Biogen, and both Paul and Kerri (as well as their colleagues at Scripps), we co-founded Padlock with the aim of translating these insights into therapies in autoimmunity. In the summer of 2013, we got excited about the role of peptidyl arginine deiminases (PADs) in driving antigenic citrullination, based on cutting-edge research from The Scripps Research Institute in particular, research from Paul Thompson (now at UMass) into the biochemistry and structure of PADs, and Kerri Mowen into the biologic relevance of these enzymes. As I describe later, we had a number of attractive strategic options in front of us, but in the end BMS and its commitment to exploring the Padlock’s biology in autoimmunity won the day.īefore sharing a few reflections, here’s the history of the deal. We certainly never anticipated exiting our investment within two years, but Padlock’s trajectory and R&D progress has been staggeringly fast and attracted the interest of multiple suitors late last year. Today we announced the acquisition of Padlock Therapeutics by BMS for up to $600M in total deal value ( here), bringing a bittersweet end to a great startup story and the start of a promising and likely productive portfolio for BMS.